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Jocelyne Bloch: The brain may be able to repair itself -- with help
Jocelyne Bloch: Mozak se sam može popraviti – uz pomoć
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Od liječenja svega od moždanih udara do ozlijeda nastalih u prometnim nesrećama, neurokirurg Jocelyne Bloch jako dobro zna kako se teško mozak oporavlja. Ali sada predlaže da je sa svojim kolegama možda pronašla ključ popravka: Doublecortin-pozitivne stanice. Slične matičnim stanicama, iznimno su prilagodljive i, izvađene iz mozga, kultivirane i ponovo ubrizgane u ozlijeđeno područje, mogu ga pomoći obnoviti. “Uz malu pomoć,” kaže, “mozak si može sam pomoći.”
Jocelyne Bloch - Functional neurosurgeon
Jocelyne Bloch is helping to unlock potential self-healing capacities of the human brain. Full bio
Jocelyne Bloch is helping to unlock potential self-healing capacities of the human brain. Full bio
Double-click the English transcript below to play the video.
00:12
So I'm a neurosurgeon.
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Ja sam neurokirurg.
00:15
And like most of my colleagues,
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I kao većina mojih kolega,
00:17
I have to deal, every day,
with human tragedies.
with human tragedies.
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svaki sam dan suočena
s ljudskim tragedijama.
s ljudskim tragedijama.
00:22
I realize how your life can change
from one second to the other
from one second to the other
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Razumijem kako se život može
promijeniti iz sekunde u sekundu
promijeniti iz sekunde u sekundu
00:27
after a major stroke
or after a car accident.
or after a car accident.
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nakon teškog moždanog udara
ili nakon prometne nesreće.
ili nakon prometne nesreće.
00:32
And what is very frustrating
for us neurosurgeons
for us neurosurgeons
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Vrlo je frustrirajuće
nama neurokirurzima
nama neurokirurzima
00:35
is to realize that unlike
other organs of the body,
other organs of the body,
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shvatiti da za razliku od
ostalih organa u tijelu,
ostalih organa u tijelu,
00:40
the brain has very little
ability for self-repair.
ability for self-repair.
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mozak ima jako male
mogućnosti samostalnog popravka.
mogućnosti samostalnog popravka.
00:45
And after a major injury
of your central nervous system,
of your central nervous system,
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Nakon teže ozlijede
središnjeg živčanog sustava,
središnjeg živčanog sustava,
00:50
the patients often remain
with a severe handicap.
with a severe handicap.
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pacijentima često ostaju
trajne posljedice.
trajne posljedice.
00:55
And that's probably
the reason why I've chosen
the reason why I've chosen
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To je vjerojatno razlog
zašto sam odlučila
zašto sam odlučila
00:57
to be a functional neurosurgeon.
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biti funkcionalni neurokirurg.
01:01
What is a functional neurosurgeon?
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Što je funkcionalni neurokirurg?
01:03
It's a doctor who is trying to improve
a neurological function
a neurological function
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To je liječnik koji pokušava
poboljšati neurološke funkcije
poboljšati neurološke funkcije
01:08
through different surgical strategies.
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uz pomoć raznih kirurških tehnika.
01:12
You've certainly heard of
one of the famous ones
one of the famous ones
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Sigurno ste čuli
za jednu od poznatijih
za jednu od poznatijih
01:14
called deep brain stimulation,
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poput duboke moždane stimulacije,
01:17
where you implant an electrode
in the depths of the brain
in the depths of the brain
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kod koje se elektroda usađuje
u dubinu mozga
u dubinu mozga
01:21
in order to modulate a circuit of neurons
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kako bi upravljali sklopom neurona
01:24
to improve a neurological function.
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i poboljšali neurološku funkciju.
01:27
It's really an amazing technology
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Uistinu je nevjerojatna tehnologija
01:29
in that it has improved
the destiny of patients
the destiny of patients
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po tome što je poboljšala
sudbinu pacijenata
sudbinu pacijenata
01:32
with Parkinson's disease,
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s Parkinsonovom bolešću,
01:34
with severe tremor, with severe pain.
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s teškim tremorom, sa snažnim bolovima.
01:38
However, neuromodulation
does not mean neuro-repair.
does not mean neuro-repair.
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Međutim, neuromodulacija
ne znači popravak.
ne znači popravak.
01:45
And the dream of functional neurosurgeons
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I san funkcionalnih neurokirurga
01:47
is to repair the brain.
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je popraviti mozak.
01:51
I think
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Mislim
01:52
that we are approaching this dream.
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da se približavamo ovom snu.
01:54
And I would like to show you
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Željela bih vam pokazati
01:57
that we are very close to this.
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da smo vrlo blizu tome.
02:00
And that with a little bit of help,
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Uz vrlo malu pomoć,
02:03
the brain is able to help itself.
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mozak si može sam pomoći.
02:08
So the story started 15 years ago.
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Priča je počela prije 15 godina.
02:11
At that time, I was a chief resident
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U to sam vrijeme bila
glavni specijalizant,
glavni specijalizant,
02:13
working days and nights
in the emergency room.
in the emergency room.
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radila danju i noću
u hitnoj službi.
u hitnoj službi.
02:16
I often had to take care
of patients with head trauma.
of patients with head trauma.
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Često sam skrbila o
pacijentima s traumama glave.
pacijentima s traumama glave.
02:21
You have to imagine that when a patient
comes in with a severe head trauma,
comes in with a severe head trauma,
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Morate pretpostaviti da kada vam
pacijent dođe s teškom traumom glave,
pacijent dođe s teškom traumom glave,
02:25
his brain is swelling
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njegov mozak otiče
02:28
and he's increasing
his intracranial pressure.
his intracranial pressure.
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i intakranijski tlak raste.
02:31
And in order to save his life,
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Kako bi spasili njegov život,
02:33
you have to decrease
this intracranial pressure.
this intracranial pressure.
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morate smanjiti taj
intrakranijalni tlak.
intrakranijalni tlak.
02:36
And to do that,
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Da bi to učinili,
02:37
you sometimes have to remove
a piece of swollen brain.
a piece of swollen brain.
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nekada morate ukloniti dio
oteknutog mozga.
oteknutog mozga.
02:42
So instead of throwing away
these pieces of swollen brain,
these pieces of swollen brain,
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Ali umjesto bacanja tih
komada oteknutog mozga,
komada oteknutog mozga,
02:46
we decided with Jean-François Brunet,
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odlučili smo, sa Jean-François Brunetom,
02:49
who is a colleague of mine, a biologist,
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koji je moj kolega, biolog,
02:51
to study them.
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proučavati ih.
02:53
What do I mean by that?
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Što time mislim?
02:55
We wanted to grow cells
from these pieces of tissue.
from these pieces of tissue.
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Htjeli smo uzgojiti stanice
iz tih komada tkiva.
iz tih komada tkiva.
03:00
It's not an easy task.
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To nije jednostavan zadatak.
03:02
Growing cells from a piece of tissue
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Uzgajanje stanica iz komada tkiva
03:04
is a bit the same as growing
very small children
very small children
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gotovo je isto kao razvijanje
vrlo male djece
vrlo male djece
03:08
out from their family.
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iz njihove obitelji.
03:11
So you need to find the right nutrients,
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Morate naći prave hranjive tvari,
03:14
the warmth, the humidity
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toplinu, vlagu,
03:15
and all the nice environments
to make them thrive.
to make them thrive.
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i pravu okolinu
kako bi napredovali.
kako bi napredovali.
03:19
So that's exactly what we had
to do with these cells.
to do with these cells.
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Upravo smo to morali učiniti
s ovim stanicama.
s ovim stanicama.
03:22
And after many attempts,
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Nakon brojnih pokušaja,
03:24
Jean-François did it.
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Jean-François je uspio.
03:27
And that's what he saw
under his microscope.
under his microscope.
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I to je vidio pod
svojim mikroskopom.
svojim mikroskopom.
03:31
And that was, for us, a major surprise.
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To je za nas bilo veliko iznenađenje.
03:34
Why?
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Zašto?
03:35
Because this looks exactly the same
as a stem cell culture,
as a stem cell culture,
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Zato što ovo izgleda potpuno isto
kao kultura matičnih stanica,
kao kultura matičnih stanica,
03:40
with large green cells
surrounding small, immature cells.
surrounding small, immature cells.
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s velikim zelenim stanicama
koje okružuju male, nezrele stanice.
koje okružuju male, nezrele stanice.
03:47
And you may remember from biology class
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Možda se sjećate sa sati biologije
03:50
that stem cells are immature cells,
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da su matične stanice nezrele stanice,
03:53
able to turn into any type
of cell of the body.
of cell of the body.
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koje se mogu pretvoriti u
bilo koji tip stanica u tijelu.
bilo koji tip stanica u tijelu.
03:59
The adult brain has stem cells,
but they're very rare
but they're very rare
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Mozak odraslog čovjeka ima
matične stanice, ali jako su rijetke
matične stanice, ali jako su rijetke
04:04
and they're located
in deep and small niches
in deep and small niches
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i nalaze se duboko u
malim udubinama
malim udubinama
04:08
in the depths of the brain.
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u dubinama mozga.
04:10
So it was surprising to get
this kind of stem cell culture
this kind of stem cell culture
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Iznenadilo nas je što smo dobili
ovakvu kulturu matičnih stanica
ovakvu kulturu matičnih stanica
04:14
from the superficial part
of swollen brain we had
of swollen brain we had
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iz površinskog sloja otečenog
mozga kojeg smo imali
mozga kojeg smo imali
04:16
in the operating theater.
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u operacijskoj sali.
04:18
And there was another
intriguing observation:
intriguing observation:
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Primjetili smo
još nešto zanimljivo:
još nešto zanimljivo:
04:21
Regular stem cells
are very active cells --
are very active cells --
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Normalne su matične
stanice vrlo aktivne stanice -
stanice vrlo aktivne stanice -
04:26
cells that divide, divide,
divide very quickly.
divide very quickly.
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stanice koje se dijele, dijele,
dijele vrlo brzo.
dijele vrlo brzo.
04:30
And they never die,
they're immortal cells.
they're immortal cells.
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I nikad ne umiru,
besmrtne su stanice.
besmrtne su stanice.
04:33
But these cells behave differently.
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Ali ove se stanice ponašaju drugačije.
04:36
They divide slowly,
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Dijele se polako,
04:38
and after a few weeks of culture,
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i nakon nekoliko tjedana kultiviranja,
04:40
they even died.
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čak su i umrle.
04:43
So we were in front of a strange
new cell population
new cell population
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Bili smo pred čudnom
novom populacijom stanica
novom populacijom stanica
04:46
that looked like stem cells
but behaved differently.
but behaved differently.
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koje su izgledale kao matične stanice
ali su se ponašale drugačije.
ali su se ponašale drugačije.
04:51
And it took us a long time
to understand where they came from.
to understand where they came from.
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Trebalo nam je dugo vremena
da bi shvatili odakle su došle.
da bi shvatili odakle su došle.
04:55
They come from these cells.
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Došle su od ovih stanica.
04:58
These blue and red cells are called
doublecortin-positive cells.
doublecortin-positive cells.
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Ove plave i crvene stanice su
doublecortin-pozitivne stanice.
doublecortin-pozitivne stanice.
05:04
All of you have them in your brain.
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Svi ih imate u svom mozgu.
05:07
They represent four percent
of your cortical brain cells.
of your cortical brain cells.
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Predstavljaju četiri posto
kortikalnih stanica.
kortikalnih stanica.
05:11
They have a very important role
during the development stage.
during the development stage.
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One imaju vrlo važnu
ulogu tijekom razvoja.
ulogu tijekom razvoja.
05:15
When you were fetuses,
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Kad ste bili fetusi,
05:18
they helped your brain to fold itself.
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pomogle su u razvoju vašeg mozga.
05:22
But why do they stay in your head?
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Ali zašto ostaju u glavi?
05:25
This, we don't know.
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Ovo ne znamo.
05:27
We think that they may
participate in brain repair
participate in brain repair
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Mislimo da možda imaju
ulogu u oporavku mozga
ulogu u oporavku mozga
05:30
because we find them
in higher concentration
in higher concentration
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jer ih nalazimo
u većoj koncentraciji
u većoj koncentraciji
05:34
close to brain lesions.
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u blizini moždanih lezija.
05:35
But it's not so sure.
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Ali nije sigurno.
05:37
But there is one clear thing --
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No jedna je stvar jasna -
05:40
that from these cells,
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da smo iz ovih stanica,
05:41
we got our stem cell culture.
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dobili našu kulturu matičnih stanica.
05:45
And we were in front
of a potential new source of cells
of a potential new source of cells
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Bili smo pred potencijalnim
novim izvorom stanica
novim izvorom stanica
05:48
to repair the brain.
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za popravak mozga.
05:50
And we had to prove this.
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I morali smo ovo dokazati.
05:51
So to prove it,
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A da bi to dokazali,
05:52
we decided to design
an experimental paradigm.
an experimental paradigm.
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odlučili smo dizajnirati
eksperimentalni primjer.
eksperimentalni primjer.
05:56
The idea was to biopsy a piece of brain
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Ideja je bila biopirati dio mozga
05:59
in a non-eloquent area of the brain,
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u dijelu mozga koji nije ključan
06:02
and then to culture the cells
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i zatim kultivirati stanice
06:04
exactly the way Jean-François
did it in his lab.
did it in his lab.
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točno onako kako je to Jean-François
učinio u svom laboratoriju.
učinio u svom laboratoriju.
06:07
And then label them, to put color in them
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I zatim ih označiti, obojati ih
06:10
in order to be able
to track them in the brain.
to track them in the brain.
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kako bismo ih mogli
pratiti u mozgu.
pratiti u mozgu.
06:13
And the last step was to re-implant them
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Zadnji je korak bio ponovo ih ugraditi
06:15
in the same individual.
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u istu jedinku.
06:17
We call these
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To zovemo
06:18
autologous grafts -- autografts.
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autolognim graftovima - autografovima.
06:21
So the first question we had,
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Prvo pitanje koje smo imali,
06:24
"What will happen if we re-implant
these cells in a normal brain,
these cells in a normal brain,
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"Što će se dogoditi ako reimplantiramo
ove stanice u normalan mozak,
ove stanice u normalan mozak,
06:29
and what will happen
if we re-implant the same cells
if we re-implant the same cells
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i što će se dogoditi ako
reimplantiramo iste stanice
reimplantiramo iste stanice
06:32
in a lesioned brain?"
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u ozlijeđeni mozak?"
06:33
Thanks to the help
of professor Eric Rouiller,
of professor Eric Rouiller,
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Zahvaljujući pomoći
profesora Erica Rouillera,
profesora Erica Rouillera,
06:36
we worked with monkeys.
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radili smo s majmunima.
06:39
So in the first-case scenario,
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U prvom scenariju,
06:41
we re-implanted the cells
in the normal brain
in the normal brain
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reimplantirali smo stanice
u normalan mozak
u normalan mozak
06:45
and what we saw is that they completely
disappeared after a few weeks,
disappeared after a few weeks,
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i primjetili da one potpuno nestaju
nakon prvih nekoliko tjedana,
nakon prvih nekoliko tjedana,
06:50
as if they were taken from the brain,
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kao da su odnešene iz mozga,
06:53
they go back home,
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odu natrag kući,
06:54
the space is already busy,
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taj je prostor već zauzet,
06:56
they are not needed there,
so they disappear.
so they disappear.
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nisu tamo potrebne,
i nestanu.
i nestanu.
06:59
In the second-case scenario,
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U drugom slučaju,
07:01
we performed the lesion,
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izvršili smo leziju,
07:03
we re-implanted exactly the same cells,
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reimplantirali iste te stanice,
07:06
and in this case, the cells remained --
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ali sada, stanice su ostale tu -
07:10
and they became mature neurons.
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i postale zreli neuroni.
07:13
And that's the image of what
we could observe under the microscope.
we could observe under the microscope.
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I to je slika onoga što smo mogli
vidjeti pod mikroskopom.
vidjeti pod mikroskopom.
07:17
Those are the cells
that were re-implanted.
that were re-implanted.
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To su stanice koje
smo reimplantirali.
smo reimplantirali.
07:20
And the proof they carry,
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I dokaz nose na sebi,
07:22
these little spots, those
are the cells that we've labeled
are the cells that we've labeled
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ove male točkice, to su
stanice koje smo obojili
stanice koje smo obojili
07:26
in vitro, when they were in culture.
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in vitro, dok su još bile u kulturi.
07:29
But we could not stop here, of course.
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Ali, naravno, nismo tu mogli stati.
07:32
Do these cells also help a monkey
to recover after a lesion?
to recover after a lesion?
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Pomažu li ove stanice majmunu
u oporavku nakon lezije?
u oporavku nakon lezije?
07:37
So for that, we trained monkeys
to perform a manual dexterity task.
to perform a manual dexterity task.
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Za to smo trenirali majmune
da izvrše test manualne spretnosti.
da izvrše test manualne spretnosti.
07:42
They had to retrieve
food pellets from a tray.
food pellets from a tray.
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Morali su dohvatiti komadiće
hrane iz posudica.
hrane iz posudica.
07:45
They were very good at it.
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Bili su vrlo dobri u tome.
07:47
And when they had reached
a plateau of performance,
a plateau of performance,
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I kad su dostigli vrhunac
spretnosti,
spretnosti,
07:51
we did a lesion in the motor cortex
corresponding to the hand motion.
corresponding to the hand motion.
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načinili smo leziju u motoričkom
korteksu odgovornom za pokrete ruku.
korteksu odgovornom za pokrete ruku.
07:57
So the monkeys were plegic,
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Majmuni su bili plegični,
07:59
they could not move their hand anymore.
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nisu više mogli micati rukama.
08:02
And exactly the same as humans would do,
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I isto kao i kod ljudi,
08:05
they spontaneously recovered
to a certain extent,
to a certain extent,
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spontano su se oporavili
do određene mjere,
do određene mjere,
08:08
exactly the same as after a stroke.
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potpuno isto kao i nakon moždanog udara.
08:10
Patients are completely plegic,
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Pacijenti su potpuno plegični,
08:12
and then they try to recover
due to a brain plasticity mechanism,
due to a brain plasticity mechanism,
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i pokušaju se oporaviti zahvaljujući
mehanizmu plastičnosti mozga,
mehanizmu plastičnosti mozga,
08:17
they recover to a certain extent,
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oporave se do određene mjere,
08:19
exactly the same for the monkey.
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isto kao i kod majmuna.
08:21
So when we were sure that the monkey
had reached his plateau
had reached his plateau
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Kad smo bili sigurni da je
majmun dosegao vrhunac
majmun dosegao vrhunac
08:24
of spontaneous recovery,
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spontanog oporavka,
08:27
we implanted his own cells.
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implantirali smo njegove stanice.
08:30
So on the left side, you see the monkey
that has spontaneously recovered.
that has spontaneously recovered.
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Na lijevoj strani vidite majmuna
koji se spontano oporavio.
koji se spontano oporavio.
08:37
He's at about 40 to 50 percent
of his previous performance
of his previous performance
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Sada je na 40 do 50 posto
prijašnjih performansi
prijašnjih performansi
08:42
before the lesion.
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prije lezije.
08:44
He's not so accurate, not so quick.
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Nije tako precizan, niti brz.
08:47
And look now, when we re-impant the cells:
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I pogledajte sada, kada
reimplantiramo stanice:
reimplantiramo stanice:
08:50
Two months after re-implantation,
the same individual.
the same individual.
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Dva mjeseca nakon
reimplantacije, ista jedinka.
reimplantacije, ista jedinka.
08:57
(Applause)
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(Pljesak)
09:04
It was also very exciting results
for us, I tell you.
for us, I tell you.
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To su bili vrlo dobri rezultati
za nas, kažem vam.
za nas, kažem vam.
09:09
Since that time, we've understood
much more about these cells.
much more about these cells.
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Otada, shvatili smo mnogo
više o ovim stanicama.
više o ovim stanicama.
09:13
We know that we can cryopreserve them,
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Znamo da ih možemo krioprezervirati,
09:15
we can use them later on.
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možemo ih koristiti kasnije.
09:18
We know that we can apply them
in other neuropathological models,
in other neuropathological models,
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Znamo da ih možemo koristiti u
drugim neuropatološkim oblicima,
drugim neuropatološkim oblicima,
09:22
like Parkinson's disease, for example.
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poput Parkinsonove bolesti, na primjer.
09:24
But our dream is still
to implant them in humans.
to implant them in humans.
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Ali naš je san i dalje
implantirati ih u ljude.
implantirati ih u ljude.
09:28
And I really hope that I'll be able
to show you soon
to show you soon
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I uistinu se nadam da ću vam
uskoro moći pokazati
uskoro moći pokazati
09:33
that the human brain is giving us
the tools to repair itself.
the tools to repair itself.
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da nam ljudski mozak daje alate
za samostalan popravak.
za samostalan popravak.
09:38
Thank you.
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Hvala vam.
09:39
(Applause)
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(Pljesak)
09:45
Bruno Giussani: Jocelyne, this is amazing,
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Bruno Giussani: Jocelyne,
ovo je nevjerojatno,
ovo je nevjerojatno,
09:49
and I'm sure that right now, there are
several dozen people in the audience,
several dozen people in the audience,
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sugran sam da sada
deseci ljudi u publici,
deseci ljudi u publici,
09:53
possibly even a majority,
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vjerojatno čak i većina,
09:54
who are thinking, "I know
somebody who can use this."
somebody who can use this."
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razmišljaju, "Znam nekoga
kome bi ovo pomoglo."
kome bi ovo pomoglo."
09:57
I do, in any case.
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Ja razmišljam o tome,
u svakom slučaju.
u svakom slučaju.
09:59
And of course the question is,
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Naravno, pitanje je,
10:01
what are the biggest obstacles
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koje su najveće prepreke
10:03
before you can go
into human clinical trials?
into human clinical trials?
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u kliničkim studijama
na ljudima?
na ljudima?
10:07
Jocelyne Bloch: The biggest
obstacles are regulations. (Laughs)
obstacles are regulations. (Laughs)
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Jocelyne Bloch: Najveća su
prepreka propisi. (Smijeh)
prepreka propisi. (Smijeh)
10:13
So, from these exciting results,
you need to fill out
you need to fill out
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Od ovih uzbudljivih rezultata,
morete popuniti
morete popuniti
10:15
about two kilograms of papers and forms
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oko dva kilograma papirologije
10:19
to be able to go through these
kind of trials.
kind of trials.
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da bi ova testiranja
mogla nastaviti
mogla nastaviti
10:22
BG: Which is understandable,
the brain is delicate, etc.
the brain is delicate, etc.
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BG: Što je razumljivo,
mozak je delikatan, itd.
mozak je delikatan, itd.
10:24
JB: Yes, it is, but it takes a long time
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JB: Da, jest, ali potrebno je puno vremena
10:27
and a lot of patience and almost
a professional team to do it, you know?
a professional team to do it, you know?
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i mnogo strpljenja i gotovo
profesionalan tim za to, znate?
profesionalan tim za to, znate?
10:31
BG: If you project yourself --
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BG: Ako možete projicirati -
10:33
having done the research
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napravili ste istraživanje
10:34
and having tried to get
permission to start the trials,
permission to start the trials,
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i tražili ste odobrenje za
početak studija,
početak studija,
10:38
if you project yourself out in time,
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ako možete predvidjeti,
10:42
how many years before
somebody gets into a hospital
somebody gets into a hospital
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koliko je potrebno godina
da kada netko dođe u bolnicu
da kada netko dođe u bolnicu
10:46
and this therapy is available?
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ima ovu terapiju dostupnu?
10:49
JB: So, it's very difficult to say.
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JB: Vrlo je teško reći.
10:51
It depends, first,
on the approval of the trial.
on the approval of the trial.
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Ovisi, prvo,
o odobrenju studija
o odobrenju studija
10:55
Will the regulation allow us
to do it soon?
to do it soon?
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Hoće li nam propisi dozvoliti
da krenemo uskoro?
da krenemo uskoro?
10:58
And then, you have to perform
this kind of study
this kind of study
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I zatim, morate napraviti
ovakvu studiju
ovakvu studiju
11:01
in a small group of patients.
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na maloj skupini pacijenata.
11:04
So it takes, already, a long time
to select the patients,
to select the patients,
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Potrebno je dosta vremena za
odabir pacijenata,
odabir pacijenata,
11:07
do the treatment
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za provođenje terapije
11:09
and evaluate if it's useful
to do this kind of treatment.
to do this kind of treatment.
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i procjenu je li ovakvo
liječenje potrebno.
liječenje potrebno.
11:13
And then you have to deploy
this to a multicentric trial.
this to a multicentric trial.
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I zatim morate razviti
multicentričnu studiju.
multicentričnu studiju.
11:17
You have to really prove
first that it's useful
first that it's useful
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Morate prvo dokazati
da je korisno
da je korisno
11:21
before offering this treatment
up for everybody.
up for everybody.
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prije nego ovu terapiju
ponudite svima.
ponudite svima.
11:24
BG: And safe, of course. JB: Of course.
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BG: I sigurno, naravno. JB: Naravno.
11:26
BG: Jocelyne, thank you for coming
to TED and sharing this.
to TED and sharing this.
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BG: Jocelyne, hvala vam što ste došli
na TED podijeliti ovo.
na TED podijeliti ovo.
11:29
BG: Thank you.
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BG: Hvala vam.
11:30
(Applause)
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(Pljesak)
ABOUT THE SPEAKER
Jocelyne Bloch - Functional neurosurgeonJocelyne Bloch is helping to unlock potential self-healing capacities of the human brain.
Why you should listen
Swiss neurosurgeon Jocelyne Bloch is an expert in deep brain stimulation and neuromodulation for movement disorders. Her recent work focuses on cortical cells, called doublecortin, related to neurogenesis and brain repair. In collaboration with Jean François Brunet and others, she is pioneering the development of adult brain cell transplantation for patients with stroke, using their own stem cells. She aims at gathering all these novel therapeutic strategies under a common umbrella that will optimize treatment options for patients suffering from neurological impairments. She is in charge of the functional neurosurgery unit at the Lausanne University Hospital (CHUV).
Jocelyne Bloch | Speaker | TED.com