Jocelyne Bloch: The brain may be able to repair itself -- with help
Jocelyne Bloch: 只需要一點幫忙,腦部或許能自我修復。
Jocelyne Bloch is helping to unlock potential self-healing capacities of the human brain. Full bio
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with human tragedies.
from one second to the other
嚴重中風或車禍,
or after a car accident.
for us neurosurgeons
other organs of the body,
ability for self-repair.
of your central nervous system,
受到嚴重受創後,
with a severe handicap.
the reason why I've chosen
做什麼工作呢?
a neurological function
one of the famous ones
in the depths of the brain
the destiny of patients
does not mean neuro-repair.
in the emergency room.
of patients with head trauma.
comes in with a severe head trauma,
受到重創入院,
his intracranial pressure.
this intracranial pressure.
a piece of swollen brain.
腫脹的腦組織。
these pieces of swollen brain,
from these pieces of tissue.
培育細胞。
very small children
to make them thrive.
使他們茁壯成長。
to do with these cells.
這些細胞的想法。
under his microscope.
as a stem cell culture,
幹細胞一樣,
surrounding small, immature cells.
未長成的小細胞。
of cell of the body.
but they're very rare
但十分稀少。
in deep and small niches
this kind of stem cell culture
腫脹的腦部表面,
of swollen brain we had
intriguing observation:
are very active cells --
divide very quickly.
they're immortal cells.
new cell population
奇怪的新細胞,
but behaved differently.
to understand where they came from.
才知道它們從那
doublecortin-positive cells.
微管相關蛋白正向細胞。
of your cortical brain cells.
during the development stage.
大家的腦部呢?
participate in brain repair
in higher concentration
在腦損傷的附近
of a potential new source of cells
就在我們面前,
an experimental paradigm.
did it in his lab.
試驗的方法一樣。
to track them in the brain.
these cells in a normal brain,
在正常腦部,會有什麼事;
if we re-implant the same cells
of professor Eric Rouiller,
in the normal brain
在正常的腦部,
disappeared after a few weeks,
這些細胞完全消失,
so they disappear.
唯有自行消失。
we could observe under the microscope.
觀察到的影像。
that were re-implanted.
are the cells that we've labeled
to recover after a lesion?
有腦創傷的猴子恢復呢?
to perform a manual dexterity task.
手指靈巧的動作。
food pellets from a tray.
a plateau of performance,
corresponding to the hand motion.
皮質做了一個傷口。
to a certain extent,
due to a brain plasticity mechanism,
可塑性機制,
had reached his plateau
that has spontaneously recovered.
已經自行恢復。
of his previous performance
the same individual.
for us, I tell you.
much more about these cells.
in other neuropathological models,
神經病理模式。
to implant them in humans.
把細胞植入人腦。
to show you soon
the tools to repair itself.
人體自我修復的功具。
several dozen people in the audience,
somebody who can use this."
接受這個治療。」
into human clinical trials?
obstacles are regulations. (Laughs)
就是規條。(笑聲)
you need to fill out
kind of trials.
the brain is delicate, etc.
a professional team to do it, you know?
permission to start the trials,
somebody gets into a hospital
on the approval of the trial.
to do it soon?
盡快做試驗呢?
this kind of study
to select the patients,
to do this kind of treatment.
this to a multicentric trial.
first that it's useful
up for everybody.
JB:一定。
to TED and sharing this.
跟我們分享這些見解。
ABOUT THE SPEAKER
Jocelyne Bloch - Functional neurosurgeonJocelyne Bloch is helping to unlock potential self-healing capacities of the human brain.
Why you should listen
Swiss neurosurgeon Jocelyne Bloch is an expert in deep brain stimulation and neuromodulation for movement disorders. Her recent work focuses on cortical cells, called doublecortin, related to neurogenesis and brain repair. In collaboration with Jean François Brunet and others, she is pioneering the development of adult brain cell transplantation for patients with stroke, using their own stem cells. She aims at gathering all these novel therapeutic strategies under a common umbrella that will optimize treatment options for patients suffering from neurological impairments. She is in charge of the functional neurosurgery unit at the Lausanne University Hospital (CHUV).
Jocelyne Bloch | Speaker | TED.com