Jennifer Pluznick: You smell with your body, not just your nose
Jennifer Pluznick: I vaše tijelo može njušiti, ne samo vaš nos
Jennifer Pluznick is on a mission to find out more about olfactory and other sensory receptors. Full bio
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do you think you can smell,
da možete nanjušiti,
detect up to one trillion different odors.
prepoznati do trilijun različitih mirisa.
machinery to make it happen.
koji je u stanju to omogućiti.
to be activated by the odor,
aktivira miris,
like all vertebrates,
poput svih kralježnjaka,
to genes for different olfactory receptors
za različite olfaktorne receptore,
be doing something else
mogli služiti još nečemu,
uncovered the molecular identity
otkrili su molekularni identitet
led to a Nobel Prize.
were only found in the nose.
ovi receptori nalaze samo u nosu.
receptor expressed in a tissue
receptoru koji se pojavio u tkivu
još jedno takvo izvješće
are found all over the body,
mogu pronaći po čitavom tijelu,
unexpected places --
neočekivana mjesta,
act as sensitive chemical sensors
ponašaju kao osjetljivi kemijski senzori
our sense of smell.
našem osjetilu njuha.
as sensitive chemical sensors
kao osjetljvi kemijski senzori
detect the aroma of your morning coffee
aromu vaše jutarnje kave
your morning coffee,
svoju jutarnju kavu,
olfaktorni receptor
the change in concentration
promjenu u koncentraciji
through your bloodstream.
use chemical sensors,
koriste kemijske senzore,
of hormones, metabolites
hormona, metabolita
are olfactory receptors.
su olfaktorni receptori.
of a specific molecule,
određene molekule,
found outside the nose
pronađenog izvan nosa,
express an olfactory receptor,
ima olfaktorni receptor
will seek out the chemical
tražiti kemikaliju
will swim toward the ligand.
with the highest ligand concentration?
koncentracijom liganada?
because it clearly demonstrates
is to be a chemical sensor,
to da bude kemijski senzor,
implicated in muscle cell migration,
sudjeluju u migraciji mišićnih stanica,
and respond to inhaled chemicals,
odgovore na udahnute kemikalije
to be found only in the tongue,
mislilo da se nalaze isključivo na jeziku,
in cells and tissues throughout the body.
u stanicama i tkivima u cijelom tijelu.
also play a role in our blood vessels.
igraju ulogu i u našim krvnim žilama.
of olfactory receptors and taste receptors
olfaktornih i okusnih receptora
control center for homeostasis.
centar za homeostazu.
control center would be a logical place
kontrolni centar bio logično mjesto
of different olfactory and taste receptors
različitih olfaktornih i okusnih receptora
olfaktorni receptor 78,
in cells and tissues
in the regulation of blood pressure.
was found to respond
short-chain fatty acids
masne kiseline kratkog lanca,
that reside in your gut --
živi u vašem crijevu,
by your gut microbiota,
mikrobiota proizvede,
into your bloodstream
se apsorbiraju u vaš krvotok,
interact with receptors
in metabolism of your gut microbiota
vaše crijevne makrobiote
of different olfactory and taste receptors
različitih olfaktornih i okusnih receptora
to tease out their different functions
njihove važne funkcije
each of them responds to.
odgovaraju svakome od njih.
for many other organs and tissues --
mnoge druge organe i tkiva --
has been studied to date.
tek mali broj receptora.
of the scope of influence
naše razumijevanje dosega utjecaja
to change our understanding
naše razumijevanje
of something we're following.
nešto što slijedimo.
ABOUT THE SPEAKER
Jennifer Pluznick - PhysiologistJennifer Pluznick is on a mission to find out more about olfactory and other sensory receptors.
Why you should listen
Jennifer Pluznick's fascination with understanding how interactions at the molecular level affect functions at the organismal level led her to pursue a Ph.D. in renal physiology from the University of Nebraska Medical Center. While researching kidney disease as part of her postdoc at Yale University, Pluznick came across scent receptors in the kidney. She initially wrote off this surprising finding as a fluke, but after taking a second look, she realized how important this discovery could be for understanding kidney function. Since 2010, Pluznick and her lab at the Johns Hopkins School of Medicine have researched the role of the olfactory signaling system. Most recently, they’ve found a possible connection between the bacteria in your gut and how your kidney manages blood pressure.
Jennifer Pluznick | Speaker | TED.com