Ellen Jorgensen: What you need to know about CRISPR
Ellen Jorgensen: Co byste měli vědět o technologii CRISPR
Ellen Jorgensen is at the leading edge of the do-it-yourself biotechnology movement, bringing scientific exploration and understanding to the public. Full bio
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it's for genome editing --
of really interesting conversations.
wiping out an entire species
is moving much faster
that govern it.
as possible understand
and their implications.
of a huge media hype,
are "easy" and "cheap."
jako "snadná" a "levná".
a little bit deeper
and the realities around CRISPR.
is damage the DNA.
of a double-strand break
processes kick in,
those repair processes
and something called a guide RNA.
I love to anthropomorphize --
that's keeping it out of the genome
Cas9 mimo genom
where it matches.
is called CRISPR.
bacterial immune system.
is that the guide RNA,
that is modular in the system;
and powerful system to use.
snadno použitelný a účinný.
protein complex together
se potloukají genomem
where the guide RNA matches,
of the double helix,
of DNA that's broken.
and shoves the two pieces back together.
obou části zpátky k sobě,
sometimes a base drops out
knock out a gene,
to do genome editing.
is a lot more interesting.
organism like people,
from our mom and one from our dad,
od matky a druhá od otce,
chromosome to repair it.
whatever you want in the center
you can stuff new DNA in,
scientific advances
is this modular targeting system.
modulárním zaměřovacím systémem.
into organisms for years, right?
strkáme už spoustu let,
targeting system,
exactly where we want it.
a lot of talk about it being cheap
přístupné veřejnosti
that say stuff like,
and engineer my genome?"
I've heard it's easy."
materials for an experiment
to hundreds of dollars,
to do the work in;
odbornou laboratoř pro práci.
outside of a professional lab.
on your kitchen table.
můžete dělat v kuchyni.
to do this kind of work.
there's a patent battle going on,
are in this incredible patent battle.
vedou neuvěřitelný boj o patent.
to watch it happen,
of fraudulent claims
my notebook here or there."
jsem podepsal tady nebo tam.“
a really hefty licensing fee
velký licenční poplatek,
basic research and you've got a lab.
a máte laboratoř.
Let's look at that claim.
that much about cells.
why some guide RNAs work really well
want to do one repair pathway
opravovat jedním způsobem
of getting the system into the cell
on a whole organism,
like blood or bone marrow --
krev nebo kostní dřeň,
of a lot of research now.
of some little girl
and putting it back
that people are going to do.
into the whole body,
do celého těla teď,
to have to use a virus.
you put the CRISPR into it,
effects of that are.
dlouhodobé důsledky.
but they're still there.
nicméně tu ale jsou.
over time with that?
that are trying to solve them,
hopefully, be solved.
not by a long shot.
„připoj se a hraj“.
working it out in your particular system,
to make a particular thing happen
jak dosáhnout konkrétních věcí
in the genome.
for an extra leg.
by thousands and thousands of scientists
of diseases in animals, for example,
modelů nemocí u zvířat,
that produce valuable chemicals
k výrobě cenných chemikálií
production and fermentation vats,
a fermentačních nádrží,
on what genes do.
fungování genů.
we should be telling,
ve spojení s CRISPR měli mluvit.
that the flashier aspects of it
CRISPR
to make CRISPR happen,
are being supported by our society.
naší společnosti.
a certain percentage of people
aby určité procento lidí
každý z nás svůj podíl.
the shepherds of CRISPR.
jejími patrony.
about these types of technologies,
the development of these technologies,
jejich vývoj a využití,
it's a positive outcome --
ABOUT THE SPEAKER
Ellen Jorgensen - Biologist, community science advocateEllen Jorgensen is at the leading edge of the do-it-yourself biotechnology movement, bringing scientific exploration and understanding to the public.
Why you should listen
In 2009, after many years of working as a molecular biologist in the biotech industry, together with TED Fellow Oliver Medvedik, Jorgensen founded Genspace, a nonprofit community laboratory dedicated to promoting citizen science and access to biotechnology. Despite criticism that bioresearch should be left to the experts, the Brooklyn-based lab continues to thrive, providing educational outreach, cultural events and a platform for science innovation at the grassroots level. At the lab, amateur and professional scientists conduct award-winning research on projects as diverse as identifying microbes that live in Earth's atmosphere and (Jorgensen's own pet project) DNA-barcoding plants, to distinguish between species that look alike but may not be closely related evolutionarily. Fast Company magazine named Genspace one of the world's "Top 10 innovative companies in education."
Ellen Jorgensen | Speaker | TED.com