"Let there be perception," was evolution's proclamation, and so it was that all creatures, from honeybees to humans, came to see the world not as it is, but as was most useful. This uncomfortable place--where what an organism's brain sees diverges from what is actually out there--is what Beau Lotto and his team at Lottolab are exploring through their dazzling art-sci experiments and public illusions. Their Bee Matrix installation, for example, places a live bee in a transparent enclosure where gallerygoers may watch it seek nectar in a virtual meadow of luminous Plexiglas flowers. (Bees, Lotto will tell you, see colors much like we humans do.) The data captured isn't just discarded, either: it's put to good use in probing scientific papers, and sometimes in more exhibits.

At their home in London’s Science Museum, the lab holds "synesthetic workshops" where kids and adults make abstract paintings that computers interpret into music, and they host regular Lates--evenings of science, music and "mass experiments." Lotto is passionate about involving people from all walks of life in research on perception--both as subjects and as fellow researchers. One such program, called "i,scientist," in fact led to the publication of the first ever peer-reviewed scientific paper written by schoolchildren ("Blackawton Bees," December 2010). It starts, "Once upon a time ..."

These and Lotto's other conjurings are slowly, charmingly bending the science of perception--and our perceptions of what science can be.