Jaap de Roode: How butterflies self-medicate
יאפ דה רוד: איך פרפרים נותנים תרופות לעצמם
Jaap de Roode studies the ecology and evolution of parasites, focusing on those that attack the monarch butterfly. Full bio
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are still the main cause
around the world.
of diseases such as T.B., malaria, HIV,
ממחלות כמו שחפת, מלריה, איידס,
and even in the United States.
die of seasonal flu.
we are creative. Right?
ourselves against these diseases.
נגד המחלות האלו.
we learn from our experiences
but now we know we're not.
אבל עכשיו אנחנו יודעים שאנחנו לא.
out there that can do it too.
שגם יכולות לעשות את זה.
to treat their intestinal parasites.
כדי לטפל בטפילים במעיים.
that other animals can do it too:
שגם חיות אחרות יכולות לעשות את זה:
sheep, goats, you name it.
is that recent discoveries are telling us
שגילויים אחרונים אומרים לנו
smaller brains can use medication too.
מוחות קטנים יותר גם יכולות להשתמש בתרופות.
as we all know,
that we have developed
to find new ways to discover drugs
דרכים חדשות לגלות תרופות
should look at these animals,
להביט בחיות האלו,
how to treat our own diseases.
איך לטפל במחלות שלנו.
monarch butterflies for the last 10 years.
for their spectacular migrations
בגלל הנדידות יוצאות הדופן שלהם
down to Mexico every year,
בגלל שהם נעשים חולים.
They get sick like me.
can tell us a lot about drugs
יכול להגיד לנו הרבה על תרופות
that monarchs get infected with
a mouthful.
חתיכת מילה.
on the outside of the butterfly
in between the scales of the butterfly.
בין הקשקשים של הפרפר.
to the monarch.
before they're even adults.
in the greenhouse growing plants,
הרבה זמן בחממות בגידול צמחים,
are extremely picky eaters.
הם אכלנים מאוד בררניים.
species of milkweed that they can use,
של אסקלפיה בהם הם יכולים להשתמש,
have cardenolides in them.
but not to monarchs.
can take up the chemicals,
and it makes them toxic
is advertise this toxicity
warning colorations
is grow plants in the greenhouse,
זה לגדל צמחים בחממה.
the tropical milkweed,
of these cardenolides.
של הקרדנולידים האלה.
They had no disease.
some of these milkweeds are medicinal,
מהאסקלפים האלה היו רפואיים,
in the monarch butterflies,
את הסימפטומים של המחלה בפרפרי מונארך,
when they are infected
לחיות יותר כשהם נדבקו
it was a crazy idea,
what if monarchs can use this?
יכולים להשתמש בזה?
as their own form of medicine?
בצמחים האלה כסוג של תרופה עצמית?
started doing experiments.
and gave them a choice:
non-medicinal milkweed.
of each species over their lifetime.
in science, was boring:
Fifty percent was not.
היה רפואי, וחמישים אחוז לא.
anything for their own welfare.
that can medicate their offspring.
on medicinal milkweed
על אסקלפיה רפואית
future offspring less sick?
over several years,
עכשיו במשך כמה שנים,
a monarch in a big cage,
את המונארך בכלוב גדול,
a non-medicinal plant on the other side,
that the monarchs lay on each plant.
שהמונארך מטילים על כל צמח.
is always the same.
זה תמיד אותו הדבר.
strongly prefer the medicinal milkweed.
מעדיפים מאוד את האסקלפיה הרפואית.
what these females are doing
of their eggs in the medicinal milkweed.
מהביצים באסקלפיה הרפואית.
is they actually transmit the parasites
זה למעשה להעביר את הטפיל
can lay their eggs on medicinal milkweed
להטיל את הביצים שלהן על אסקלפיה רפואית
future offspring less sick.
important discovery, I think,
something cool about nature,
משהו מגניב על הטבע,
more about how we should find drugs.
על איך אנחנו צריכים לחפש תרופות.
as very simple.
very sophisticated medication.
most of our drugs
רוב התרופות שלנו
including plants,
at animals to find new drugs.
על חיות כדי למצוא תרופות חדשות.
how to treat stomach upset,
איך לטפל בכאבי בטן,
how to treat bloody diarrhea.
though, is to move beyond
and give these guys more credit,
לחברה האלה יותר קרדיט,
that we tend to think of
החרקים שאנחנו נוטים לחשוב
with tiny little brains.
can also use medication
we will be treating human diseases
נטפל במחלות אנושיות
discovered by butterflies,
worth pursuing.
ABOUT THE SPEAKER
Jaap de Roode - BiologistJaap de Roode studies the ecology and evolution of parasites, focusing on those that attack the monarch butterfly.
Why you should listen
At his lab at Emory University, Jaap de Roode and his team study parasites and their hosts. Some of the questions that intrigue them: If a parasite depends on its host's survival for its own well-being, why do so many of them cause harm? In what ways are hosts able to self-medicate in order to make themselves less desirable to parasites? And are the abilities to harm hosts — and the ability of hosts to self-medicate — favored by natural selection?
The De Roode Lab focuses on the monarch butterfly and its parasites. The team has made a fascinating discovery: that female butterflies infected by a parasite choose to lay their eggs on a specific variety of milkweed that helps their offspring avoid getting sick. De Roode hopes that this insight could lead to new approaches in medications for human beings in the future.
Jaap de Roode | Speaker | TED.com