Jaap de Roode: How butterflies self-medicate
ジャープ・デ=ローデ: 自ら治療する蝶
Jaap de Roode studies the ecology and evolution of parasites, focusing on those that attack the monarch butterfly. Full bio
Double-click the English transcript below to play the video.
are still the main cause
around the world.
結核やマラリア、HIVで亡くなっています
of diseases such as T.B., malaria, HIV,
and even in the United States.
die of seasonal flu.
季節性インフルエンザで亡くなります
we are creative. Right?
ourselves against these diseases.
we learn from our experiences
but now we know we're not.
out there that can do it too.
植物を使うことができます
to treat their intestinal parasites.
生き物がいることが分かってきました
that other animals can do it too:
sheep, goats, you name it.
最近の研究によると
is that recent discoveries are telling us
薬草を用いているということです
smaller brains can use medication too.
as we all know,
that we have developed
効かなくなってしまうことです
to find new ways to discover drugs
薬を開発するために
should look at these animals,
how to treat our own diseases.
学べると思います
monarch butterflies for the last 10 years.
10年間研究してきました
for their spectacular migrations
down to Mexico every year,
They get sick like me.
can tell us a lot about drugs
that monarchs get infected with
難しい名前です
a mouthful.
on the outside of the butterfly
in between the scales of the butterfly.
小さな点のような胞子ですが
to the monarch.
before they're even adults.
温室で植物を育てています
in the greenhouse growing plants,
激しいからです
are extremely picky eaters.
species of milkweed that they can use,
何種類かありますが
have cardenolides in them.
but not to monarchs.
蝶は例外です
can take up the chemicals,
体内に取り込むことで
and it makes them toxic
is advertise this toxicity
warning colorations
温室で この植物を育てました
is grow plants in the greenhouse,
the tropical milkweed,
非常に高濃度の
熱帯性のものや
of these cardenolides.
元気な蝶もいましたが
They had no disease.
あるトウワタには薬効性があり
some of these milkweeds are medicinal,
病状を和らげるため
in the monarch butterflies,
when they are infected
ある考えが浮かびました
it was a crazy idea,
what if monarchs can use this?
これらの植物を使ったら?
as their own form of medicine?
started doing experiments.
and gave them a choice:
そうでないトウワタで
non-medicinal milkweed.
of each species over their lifetime.
植物の量を測定しました
in science, was boring:
退屈なもので
Fifty percent was not.
50%が薬効性のない植物でした
anything for their own welfare.
何もしていなかったのです
蝶に目を向けました
that can medicate their offspring.
薬草を与えるかということです
病にかかりにくくするよう
on medicinal milkweed
future offspring less sick?
卵を産み付けるか?と
続けてきましたが
over several years,
a monarch in a big cage,
両端に置いて
a non-medicinal plant on the other side,
卵の数を数えます
that the monarchs lay on each plant.
is always the same.
強く好むことがわかりました
strongly prefer the medicinal milkweed.
what these females are doing
トウワタの上に産卵しています
of their eggs in the medicinal milkweed.
is they actually transmit the parasites
病から遠ざけることができる
can lay their eggs on medicinal milkweed
産卵できることがわかりました
future offspring less sick.
important discovery, I think,
something cool about nature,
教えてくれるだけでなく
あるかもしれないからです
more about how we should find drugs.
as very simple.
very sophisticated medication.
薬物療法を利用しています
most of our drugs
including plants,
動物を調べます
at animals to find new drugs.
how to treat stomach upset,
教えてくれているのです
how to treat bloody diarrhea.
though, is to move beyond
and give these guys more credit,
ほ乳類を越えて ちっぽけな脳を持ち
that we tend to think of
小さな動物や昆虫を
with tiny little brains.
薬物療法を使うという発見は
can also use medication
蝶によって初めて見つけられた薬で
we will be treating human diseases
discovered by butterflies,
素晴らしい好機だと思います
worth pursuing.
ABOUT THE SPEAKER
Jaap de Roode - BiologistJaap de Roode studies the ecology and evolution of parasites, focusing on those that attack the monarch butterfly.
Why you should listen
At his lab at Emory University, Jaap de Roode and his team study parasites and their hosts. Some of the questions that intrigue them: If a parasite depends on its host's survival for its own well-being, why do so many of them cause harm? In what ways are hosts able to self-medicate in order to make themselves less desirable to parasites? And are the abilities to harm hosts — and the ability of hosts to self-medicate — favored by natural selection?
The De Roode Lab focuses on the monarch butterfly and its parasites. The team has made a fascinating discovery: that female butterflies infected by a parasite choose to lay their eggs on a specific variety of milkweed that helps their offspring avoid getting sick. De Roode hopes that this insight could lead to new approaches in medications for human beings in the future.
Jaap de Roode | Speaker | TED.com