TED2008
Dean Ornish: Your genes are not your fate
Dean Ornish berkata genmu bukanlah nasibmu
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Dean Ornish berbagi penelitian baru yang menunjukan bagaimana pengadopsian kebiasaan gaya hidup sehat dapat mempengaruhi seseorang pada strata genetik. Misalnya, kata Dean Ornish, ketika anda hidup lebih sehat, makan lebih baik, berolah-raga dan mencinta lebih banyak, sel-sel otak anda sebenarnya berkembang.
Dean Ornish - Physician, author
Dean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes. Full bio
Dean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes. Full bio
Double-click the English transcript below to play the video.
00:12
One way to change our genes is to make new ones,
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Satu cara untuk mengubah gen-gen kita adalah dengan membuat gen-gen baru,
00:14
as Craig Venter has so elegantly shown.
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seperti Craig Venter dengan sangat elegannya telah tunjukkan.
00:16
Another is to change our lifestyles.
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Cara lainnya adalah dengan mengubah gaya hidup kita.
00:19
And what we're learning is how powerful and dynamic these changes can be,
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Dan apa yang kita pelajari adalah betapa kuat dan dinamis perubahan-perubahan ini dapat menjadi,
00:23
that you don't have to wait very long to see the benefits.
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bahwa anda tidak perlu menunggu sangat lama untuk melihat manfaat-manfaatnya.
00:26
When you eat healthier, manage stress, exercise and love more,
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Ketika anda makan lebih sehat, mengelola stres, berolah-raga dan mencinta lebih banyak,
00:31
your brain actually gets more blood flow and more oxygen.
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otak anda sebenarnya mendapat lebih banyak aliran darah dan oksigen.
00:33
But more than that, your brain gets measurably bigger.
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Tapi lebih dari itu, otak anda bertambah besar.
00:36
Things that were thought impossible just a few years ago
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Hal-hal yang sebelumnya dikira tidak mungkin hanya beberapa tahun yang lalu
00:38
can actually be measured now.
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dapat sesungguhnya diukur sekarang.
00:40
This was figured out by Robin Williams
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Hal ini dipecahkan oleh Robin Williams
00:43
a few years before the rest of us.
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beberapa tahun sebelum kita semua.
00:45
Now, there's some things that you can do
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Sekarang, ada beberapa hal yang anda dapat lakukan
00:47
to make your brain grow new brain cells.
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untuk membuat otak anda menumbuhkan sel-sel otak baru.
00:50
Some of my favorite things, like chocolate and tea, blueberries,
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Beberapa hal favorit saya, seperti cokelat dan teh, blueberry,
00:52
alcohol in moderation, stress management
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alkohol yang sekadarnya, pengelolaan stres
00:56
and cannabinoids found in marijuana.
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dan kanabinoid yang ditemukan dalam mariyuana.
00:58
I'm just the messenger.
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Saya hanya penyampai pesan.
01:01
(Laughter)
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(Tertawa)
01:04
What were we just talking about?
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Apa yang baru saja kita bicarakan tadi?
01:07
(Laughter)
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(Tertawa)
01:09
And other things that can make it worse,
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Dan hal-hal lain yang dapat membuatnya bertambah buruk,
01:11
that can cause you to lose brain cells.
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yang dapat menyebabkan anda kehilangan sel-sel otak.
01:13
The usual suspects, like saturated fat and sugar,
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Dugaan biasa, seperti lemak jenuh dan gula,
01:16
nicotine, opiates, cocaine, too much alcohol and chronic stress.
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nikotin, candu, kokain, alkohol yang berlebihan dan stres kronis.
01:20
Your skin gets more blood flow when you change your lifestyle,
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Kulit anda mendapat lebih banyak aliran darah ketika anda mengubah gaya hidup,
01:23
so you age less quickly. Your skin doesn't wrinkle as much.
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jadi anda lambat menua, kulit anda tidak berkeriput banyak.
01:26
Your heart gets more blood flow.
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Jantung anda mendapat lebih banyak aliran darah.
01:28
We've shown that you can actually reverse heart disease.
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Kami telah tunjukkan bahwa anda sebenarnya dapat membalikkan penyakit jantung.
01:30
That these clogged arteries that you see on the upper left,
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Bahwa arteri-arteri tersumbat ini yang anda lihat di kiri atas,
01:33
after only a year become measurably less clogged.
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setelah hanya 1 tahun menjadi berkurang sumbatannya.
01:35
And the cardiac PET scan shown on the lower left,
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Dan pemindaian PET jantung yang ditunjukkan pada kiri bawah,
01:37
the blue means no blood flow.
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warna biru berarti tidak ada aliran darah.
01:39
A year later -- orange and white is maximum blood flow.
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Satu tahun kemudian -- warna oranye dan putih adalah aliran darah maksimum.
01:42
We've shown you may be able to stop and reverse the progression
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Kami telah tunjukkan anda mungkin dapat menghentikan dan membalikkan
01:45
of early prostate cancer and, by extension, breast cancer,
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progresi kanker prostat dini dan, dengan ekstensi, kanker payudara,
01:47
simply by making these changes.
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hanya dengan melakukan perubahan-perubahan ini.
01:49
We've found that tumor growth in vitro was inhibited
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Kami telah temukan bahwa pertumbuhan tumor in vitro terhambat
01:52
70 percent in the group that made these changes,
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70% dalam kelompok yang membuat perubahan-perubahan ini,
01:54
whereas only nine percent in the comparison group.
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dimana hanya 9% dalam kelompok pembanding.
01:57
These differences were highly significant.
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Perbedaan-perbedaan ini sangat signifikan.
01:59
Even your sexual organs get more blood flow,
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Bahkan organ seksual anda mendapat lebih banyak aliran darah,
02:01
so you increase sexual potency.
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jadi anda menambah potensi seksual.
02:03
One of the most effective anti-smoking ads was done
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Salah satu iklan anti rokok yang paling efektif
02:05
by the Department of Health Services,
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dibuat oleh Departemen Kesehatan,
02:07
showing that nicotine, which constricts your arteries,
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menunjukkan bahwa nikotin, yang mempersempit arteri-arteri anda,
02:09
can cause a heart attack or a stroke,
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dapat menyebabkan serangan jantung atau stroke,
02:11
but it also causes impotence.
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tapi nikotin juga dapat menyebabkan impotensi.
02:13
Half of guys who smoke are impotent.
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Separuh dari pria-pria yang merokok adalah impoten.
02:15
How sexy is that?
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Seberapa seksikah itu?
02:16
Now we're also about to publish a study --
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Sekarang kami juga akan mempublikasikan sebuah studi --
02:18
the first study showing you can change gene expression in men with prostate cancer.
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sebuah studi menunjukkan anda dapat merubah ekspresi gen pada pria penderita kanker prostat.
02:21
This is what's called a heat map --
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Inilah yang disebut sebuah pemeta panas
02:23
and the different colors -- and along the side, on the right, are different genes.
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dan warna-warna yang berbeda, dan sepanjang sisi kanan adalah gen-gen berbeda
02:26
And we found that over 500 genes were favorably changed --
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Dan kami menemukan bahwa lebih dari 500 gen secara menguntungkan diubah
02:29
in effect, turning on the good genes, the disease-preventing genes,
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sebagai pengaruh dari peralihan ke gen-gen baik, gen-gen pencegah penyakit
02:32
turning off the disease-promoting genes.
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mematikan gen-gen pendukung penyakit.
02:36
And so these findings I think are really very powerful,
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Dan jadi penemuan-penemuan ini saya rasa adalah benar-benar sangat kuasa
02:39
giving many people new hope and new choices.
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memberikan banyak orang harapan baru dan pilihan-pilihan baru
02:41
And companies like Navigenics and DNA Direct and 23andMe,
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Dan perusahaan seperti Navigenix dan DNA Direct serta 23andMe,
02:46
that are giving you your genetic profiles,
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yang memberikan anda profil genetik anda,
02:49
are giving some people a sense of, "Gosh, well, what can I do about it?"
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memberikan sebagian orang rasa, "Astaga, apa yang bisa saya lakukan?"
02:52
Well, our genes are not our fate, and if we make these changes --
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Jadi, gen kita bukanlah takdir kita, dan jika kita membuat perubahan-perubahan ini --
02:55
they're a predisposition -- but if we make bigger changes
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mereka adalah sebuah kecenderungan, tapi jika kita membuat perubahan besar
02:57
than we might have made otherwise,
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daripada yang kita mungkin perbuat sebaliknya
02:59
we can actually change how our genes are expressed.
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kita dapat sesungguhnya merubah bagaimana gen kita diekspresikan.
03:02
Thank you.
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Terima kasih
03:03
(Applause)
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(Tepuk tangan)
ABOUT THE SPEAKER
Dean Ornish - Physician, authorDean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes.
Why you should listen
Dr. Dean Ornish wants you to live longer, and have more fun while you're at it. He's one of the leading voices in the medical community promoting a balanced, holistic approach to health, and proving that it works. The author of Eat More, Weigh Less and several other best-selling books, Ornish is best known for his lifestyle-based approach to fighting heart disease.
His research at the Preventive Medicine Research Institute (the nonprofit he founded) clinically demonstrated that cardiovascular illnesses -- and, most recently prostate cancer -- can be treated and even reversed through diet and exercise. These findings (once thought to be physiologically implausible) have been widely chronicled in the US media, including Newsweek, for which Ornish writes a column. The fifty-something physician, who's received many honors and awards, was chosen by LIFE Magazine as one of the most influential members of his generation. Among his many pursuits, Ornish is now working with food corporations to help stop America's obesity pandemic from spreading around the globe.
Dean Ornish | Speaker | TED.com