ABOUT THE SPEAKER
Dean Ornish - Physician, author
Dean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes.

Why you should listen

Dr. Dean Ornish wants you to live longer, and have more fun while you're at it. He's one of the leading voices in the medical community promoting a balanced, holistic approach to health, and proving that it works. The author of Eat More, Weigh Less and several other best-selling books, Ornish is best known for his lifestyle-based approach to fighting heart disease.

His research at the Preventive Medicine Research Institute (the nonprofit he founded) clinically demonstrated that cardiovascular illnesses -- and, most recently prostate cancer -- can be treated and even reversed through diet and exercise. These findings (once thought to be physiologically implausible) have been widely chronicled in the US media, including Newsweek, for which Ornish writes a column. The fifty-something physician, who's received many honors and awards, was chosen by LIFE Magazine as one of the most influential members of his generation. Among his many pursuits, Ornish is now working with food corporations to help stop America's obesity pandemic from spreading around the globe.

More profile about the speaker
Dean Ornish | Speaker | TED.com
TED2008

Dean Ornish: Your genes are not your fate

Dean Ornish diz que os seus genes não são o seu destino

Filmed:
1,725,634 views

Dean Ornish compartilha uma nova pesquisa que mostra como a adoção de um estilo de vida saudável podem afetar a pessoa em um nível genético. Por exemplo, ele diz, quando você vive de forma mais saudável, se alimenta melhor, se exercita e ama mais, suas células cerebrais se desenvolvem.
- Physician, author
Dean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes. Full bio

Double-click the English transcript below to play the video.

00:12
One way to change our genes is to make new ones,
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Uma maneira de alterar os nossos genes é criar outros,
00:14
as Craig Venter has so elegantly shown.
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como Craig Venter tão elegantemente demonstrou.
00:16
Another is to change our lifestyles.
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Outro jeito é alterando o nosso estilo de vida.
00:19
And what we're learning is how powerful and dynamic these changes can be,
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O que estamos aprendendo é quão poderosas e dinâmicas essas mudanças podem ser,
00:23
that you don't have to wait very long to see the benefits.
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que você não precisa esperar muito tempo para ver os benefícios.
00:26
When you eat healthier, manage stress, exercise and love more,
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Quando você se alimenta de uma forma mais saudável, cuida do estresse, faz exercícios e ama mais,
00:31
your brain actually gets more blood flow and more oxygen.
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seu cérebro tem um aumento no fluxo sanguíneo e mais oxigênio.
00:33
But more than that, your brain gets measurably bigger.
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Mas mais do que isso, o seu cérebro fica mensuravelmente maior.
00:36
Things that were thought impossible just a few years ago
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Coisas que eram impossíveis alguns poucos anos atrás
00:38
can actually be measured now.
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podem ser medidas agora.
00:40
This was figured out by Robin Williams
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Isto foi percebido por Robin Williams
00:43
a few years before the rest of us.
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alguns anos antes do que pelo resto de nós.
00:45
Now, there's some things that you can do
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Existem algumas coisas que vocês podem fazer
00:47
to make your brain grow new brain cells.
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para que os seus cérebros desenvolvam novas células
00:50
Some of my favorite things, like chocolate and tea, blueberries,
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Alguma das minhas coisas favoritas, tais como chocolate e chá, amoras,
00:52
alcohol in moderation, stress management
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álcool moderado, técnicas para controlar o estresse
00:56
and cannabinoids found in marijuana.
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e canabinóides encontrados na maconha.
00:58
I'm just the messenger.
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Sou apenas o mensageiro.
01:01
(Laughter)
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(Risos)
01:04
What were we just talking about?
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Sobre o que falávamos mesmo?
01:07
(Laughter)
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(Risos)
01:09
And other things that can make it worse,
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E outras coisas que podem causar dano,
01:11
that can cause you to lose brain cells.
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que podem fazer com que vocês percam células cerebrais.
01:13
The usual suspects, like saturated fat and sugar,
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Os tradicionais suspeitos, gordura saturada e açúcar,
01:16
nicotine, opiates, cocaine, too much alcohol and chronic stress.
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nicotina, substâncias derivadas do ópio, cocaína, álcool em excesso e estresse crônico.
01:20
Your skin gets more blood flow when you change your lifestyle,
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Sua pele recebe mais sangue quando você muda o seu estilo de vida,
01:23
so you age less quickly. Your skin doesn't wrinkle as much.
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então você envelhece mais devagar, sua pele não se enruga tanto.
01:26
Your heart gets more blood flow.
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Seu coração recebe muito mais sangue.
01:28
We've shown that you can actually reverse heart disease.
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Nós demonstramos que é possível reverter doenças do coração.
01:30
That these clogged arteries that you see on the upper left,
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Que estas artérias entupidas que vocês vêem no topo à esquerda,
01:33
after only a year become measurably less clogged.
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depois de apenas um ano se tornaram comparavelmente menos entupidas.
01:35
And the cardiac PET scan shown on the lower left,
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E na tomografia cardíaca exibida abaixo à esquerda,
01:37
the blue means no blood flow.
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o azul significa ausência de fluxo sangüíneo.
01:39
A year later -- orange and white is maximum blood flow.
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Um ano depois, laranja e branco indicam máximo fluxo sangüíneo.
01:42
We've shown you may be able to stop and reverse the progression
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Demonstramos que é possível parar e reverter a progressão
01:45
of early prostate cancer and, by extension, breast cancer,
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de um início de câncer de próstata e, por extensão, câncer de mama,
01:47
simply by making these changes.
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simplesmente através dessas mudanças.
01:49
We've found that tumor growth in vitro was inhibited
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Descobrimos que tumores desenvolvidos em laboratório foram inibidos
01:52
70 percent in the group that made these changes,
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em 70 por cento no grupo que adotou estas mudanças,
01:54
whereas only nine percent in the comparison group.
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enquanto no outro grupo isso aconteceu com apenas 9 por cento.
01:57
These differences were highly significant.
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Estas diferenças foram bastante significativas.
01:59
Even your sexual organs get more blood flow,
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Até os órgãos sexuais têm um aumento no fluxo sanguíneo,
02:01
so you increase sexual potency.
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aumentando a sua potência sexual.
02:03
One of the most effective anti-smoking ads was done
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Uma das campanhas anti-fumo de maior sucesso
02:05
by the Department of Health Services,
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foi a campanha realizada pelo Departamento de Serviços de Saúde,
02:07
showing that nicotine, which constricts your arteries,
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mostrando que a nicotina, que comprime as suas artérias,
02:09
can cause a heart attack or a stroke,
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pode causar um enfarto ou derrame,
02:11
but it also causes impotence.
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mas também causa impotência.
02:13
Half of guys who smoke are impotent.
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Metade dos caras que fumam são impotentes.
02:15
How sexy is that?
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Como isso é sexy, não?
02:16
Now we're also about to publish a study --
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Atualmente estamos prestes a publicar um estudo –
02:18
the first study showing you can change gene expression in men with prostate cancer.
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o primeiro estudo mostrando que é possível mudar a expressão dos genes em homens com câncer de próstata.
02:21
This is what's called a heat map --
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Isto é chamado de mapa de calor
02:23
and the different colors -- and along the side, on the right, are different genes.
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e as diversas cores, e no lado, à direita, estão diferentes genes.
02:26
And we found that over 500 genes were favorably changed --
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Descobrimos que mais de 500 desses genes foram favoravelmente alterados
02:29
in effect, turning on the good genes, the disease-preventing genes,
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e como conseqüência ligaram os genes bons, os genes que previnem doenças,
02:32
turning off the disease-promoting genes.
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desligando os genes que causavam doenças.
02:36
And so these findings I think are really very powerful,
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Acho que estas descobertas são bastante poderosas
02:39
giving many people new hope and new choices.
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dando a muitas pessoas uma nova esperança e novas escolhas
02:41
And companies like Navigenics and DNA Direct and 23andMe,
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E companhias como Navigenix e DNA Direct e 23andMe,
02:46
that are giving you your genetic profiles,
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que estão lhe fornecendo os seus perfis genéticos,
02:49
are giving some people a sense of, "Gosh, well, what can I do about it?"
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estão dando a algumas pessoas a idéia de “Deus, bem o que posso fazer a respeito disso?”.
02:52
Well, our genes are not our fate, and if we make these changes --
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Bem, nossos genes não são o nosso destino, e se fizermos estas mudanças
02:55
they're a predisposition -- but if we make bigger changes
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eles são uma predisposição, mas se nós fizermos mudanças maiores
02:57
than we might have made otherwise,
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do que fizemos outrora,
02:59
we can actually change how our genes are expressed.
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podemos mudar a forma como os nossos genes se expressam.
03:02
Thank you.
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Obrigado.
03:03
(Applause)
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(Aplausos)
Translated by Eduardo Moeller
Reviewed by Belucio Haibara

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ABOUT THE SPEAKER
Dean Ornish - Physician, author
Dean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes.

Why you should listen

Dr. Dean Ornish wants you to live longer, and have more fun while you're at it. He's one of the leading voices in the medical community promoting a balanced, holistic approach to health, and proving that it works. The author of Eat More, Weigh Less and several other best-selling books, Ornish is best known for his lifestyle-based approach to fighting heart disease.

His research at the Preventive Medicine Research Institute (the nonprofit he founded) clinically demonstrated that cardiovascular illnesses -- and, most recently prostate cancer -- can be treated and even reversed through diet and exercise. These findings (once thought to be physiologically implausible) have been widely chronicled in the US media, including Newsweek, for which Ornish writes a column. The fifty-something physician, who's received many honors and awards, was chosen by LIFE Magazine as one of the most influential members of his generation. Among his many pursuits, Ornish is now working with food corporations to help stop America's obesity pandemic from spreading around the globe.

More profile about the speaker
Dean Ornish | Speaker | TED.com

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