TED2008
Dean Ornish: Your genes are not your fate
Dean Ornish sier at våre gener ikke bestemmer våre skjebner
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Dean Ornish deler ny forskning som viser hvordan sunne livsstil-vaner kan påvirke en person på et genetisk nivå. For eksempel, sier han, når du lever sunnere, spiser bedre, trener og elsker mer, så vil mengden hjerneceller faktisk øke.
Dean Ornish - Physician, author
Dean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes. Full bio
Dean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes. Full bio
Double-click the English transcript below to play the video.
00:12
One way to change our genes is to make new ones,
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En måte å forandre våre gener, er å lage nye,
00:14
as Craig Venter has so elegantly shown.
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som Craig Venter så elegant har vist.
00:16
Another is to change our lifestyles.
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En annen er å endre vår livsstil.
00:19
And what we're learning is how powerful and dynamic these changes can be,
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Det vi har lært er hvor kraftige og dynamiske disse forandringene kan være,
00:23
that you don't have to wait very long to see the benefits.
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at man ikke trenger å vente særlig lenge før man ser fordelene.
00:26
When you eat healthier, manage stress, exercise and love more,
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Når du spiser sunnere, takler stress, trener og elsker mer,
00:31
your brain actually gets more blood flow and more oxygen.
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vil hjernen din få mer blodtilførsel og mer oksygen.
00:33
But more than that, your brain gets measurably bigger.
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Men ikke bare det, hjernen din blir målbart større.
00:36
Things that were thought impossible just a few years ago
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Ting som vi trodde var umulig for bare noen år siden
00:38
can actually be measured now.
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kan faktisk bli målt nå.
00:40
This was figured out by Robin Williams
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Dette ble funnet ut av Robin Williams
00:43
a few years before the rest of us.
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noen år før resten av oss.
00:45
Now, there's some things that you can do
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Det er visse ting du kan gjøre
00:47
to make your brain grow new brain cells.
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for å få hjernen din til å gro nye hjerneceller.
00:50
Some of my favorite things, like chocolate and tea, blueberries,
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Noen av mine favoritter er sjokolade og te, blåbær,
00:52
alcohol in moderation, stress management
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alkohol i moderate mengder, stressmestring
00:56
and cannabinoids found in marijuana.
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og canabanoider som fins i marijuana.
00:58
I'm just the messenger.
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Jeg er bare budbringeren.
01:01
(Laughter)
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(Latter)
01:04
What were we just talking about?
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Hva var det vi snakket om?
01:07
(Laughter)
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(Latter)
01:09
And other things that can make it worse,
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Andre ting kan gjøre det verre,
01:11
that can cause you to lose brain cells.
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og forårsake tap av hjerneceller.
01:13
The usual suspects, like saturated fat and sugar,
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De vanlige synderne som mettet fett og sukker,
01:16
nicotine, opiates, cocaine, too much alcohol and chronic stress.
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nikotin, opiater, kokain, for mye alkohol og kronisk stress.
01:20
Your skin gets more blood flow when you change your lifestyle,
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Huden din får mer blodtilførsel når du endrer livsstil,
01:23
so you age less quickly. Your skin doesn't wrinkle as much.
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så du eldres langsommere, og du får ikke så mye rynker.
01:26
Your heart gets more blood flow.
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Hjertet ditt får mer blodtilførsel.
01:28
We've shown that you can actually reverse heart disease.
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Vi har vist at du kan faktisk reversere hjertesykdom.
01:30
That these clogged arteries that you see on the upper left,
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Disse tilstoppede arteriene som du ser oppe til venstre
01:33
after only a year become measurably less clogged.
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har blitt målbart mindre tilstoppet etter bare et år.
01:35
And the cardiac PET scan shown on the lower left,
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Og PET-scan av hjertet vist nede til venstre,
01:37
the blue means no blood flow.
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hvor blå betyr ingen blodgjennomstrømning.
01:39
A year later -- orange and white is maximum blood flow.
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Et år senere -- oransje og hvitt er maksimal blodgjennomstrømning.
01:42
We've shown you may be able to stop and reverse the progression
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Vi har vist at du kan være i stand til å stanse og reversere utviklingen
01:45
of early prostate cancer and, by extension, breast cancer,
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av tidlig prostata kreft, og, i forlengelsen, brystkreft,
01:47
simply by making these changes.
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simpelthen ved å gjøre disse endringene.
01:49
We've found that tumor growth in vitro was inhibited
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Vi har funnet ut at tumorvekst i laboratoriet ble hemmet
01:52
70 percent in the group that made these changes,
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70 prosent i gruppen som gjorde disse endringene,
01:54
whereas only nine percent in the comparison group.
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mot kun 9 prosent i sammenligningsgruppen.
01:57
These differences were highly significant.
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Disse forskjellene var svært signifikante.
01:59
Even your sexual organs get more blood flow,
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Til og med kjønnsorganene får mer blodtilførsel,
02:01
so you increase sexual potency.
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så du får økt potens (sexlyst).
02:03
One of the most effective anti-smoking ads was done
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En av de mest effektive anti-røykekampanjene som ble gjennomført
02:05
by the Department of Health Services,
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av Helsedepartementet,
02:07
showing that nicotine, which constricts your arteries,
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viste at nikotin, som innsnevrer dine arteriene,
02:09
can cause a heart attack or a stroke,
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kan forårsake hjerteinfarkt eller slag,
02:11
but it also causes impotence.
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men det kan også forårsake impotens.
02:13
Half of guys who smoke are impotent.
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Halvparten av menn som røyker er impotent.
02:15
How sexy is that?
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Hvor sexy er det?
02:16
Now we're also about to publish a study --
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Vi er i ferd med å publisere en studie --
02:18
the first study showing you can change gene expression in men with prostate cancer.
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den første studien som viser at du kan endre genutrykket blant menn med prostata kreft.
02:21
This is what's called a heat map --
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Dette er det som kalles et varmekart
02:23
and the different colors -- and along the side, on the right, are different genes.
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og de ulike fargene, og på høyresiden er de ulike genene.
02:26
And we found that over 500 genes were favorably changed --
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Vi fant at over 500 gener ble gunstig endret
02:29
in effect, turning on the good genes, the disease-preventing genes,
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som i praksis skrudde på de gode genene - de sykdomshemmende gener
02:32
turning off the disease-promoting genes.
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og skrudde av de sykdomsfremmende genene.
02:36
And so these findings I think are really very powerful,
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Så disse funnene mener jeg faktisk er veldig viktige
02:39
giving many people new hope and new choices.
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og gir mange folk nytt håp og nye valg.
02:41
And companies like Navigenics and DNA Direct and 23andMe,
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Og selskaper som Navigenix og DNA Direct og 23andMe,
02:46
that are giving you your genetic profiles,
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som gir deg din genetiske profil,
02:49
are giving some people a sense of, "Gosh, well, what can I do about it?"
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gir folk en følelse av: "Jøss, vel hva kan jeg gjøre med det?"
02:52
Well, our genes are not our fate, and if we make these changes --
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Vel, våre gener er ikke vår skjebne, og om vi gjør disse forandringene --
02:55
they're a predisposition -- but if we make bigger changes
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de er en predisposisjon, men om vi gjør større endringer
02:57
than we might have made otherwise,
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enn vi ville ha gjort ellers
02:59
we can actually change how our genes are expressed.
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kan vi faktisk endre hvordan våre gener er uttrykt.
03:02
Thank you.
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Takk.
03:03
(Applause)
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(Applaus)
ABOUT THE SPEAKER
Dean Ornish - Physician, authorDean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes.
Why you should listen
Dr. Dean Ornish wants you to live longer, and have more fun while you're at it. He's one of the leading voices in the medical community promoting a balanced, holistic approach to health, and proving that it works. The author of Eat More, Weigh Less and several other best-selling books, Ornish is best known for his lifestyle-based approach to fighting heart disease.
His research at the Preventive Medicine Research Institute (the nonprofit he founded) clinically demonstrated that cardiovascular illnesses -- and, most recently prostate cancer -- can be treated and even reversed through diet and exercise. These findings (once thought to be physiologically implausible) have been widely chronicled in the US media, including Newsweek, for which Ornish writes a column. The fifty-something physician, who's received many honors and awards, was chosen by LIFE Magazine as one of the most influential members of his generation. Among his many pursuits, Ornish is now working with food corporations to help stop America's obesity pandemic from spreading around the globe.
Dean Ornish | Speaker | TED.com