TED2008
Dean Ornish: Your genes are not your fate
Dean Ornish: Vaši geni nisu Vaša sudbina
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Dean Ornish saopštava novo istraživanje koje pokazuje kako usvajanje zdravih navika može uticati na ljude na genetskom nivou. Naprimjer, kaže, kada zdravije živite, bolje se hranite, vježbate i više volite, Vaše moždane ćelije se povećavaju.
Dean Ornish - Physician, author
Dean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes. Full bio
Dean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes. Full bio
Double-click the English transcript below to play the video.
00:12
One way to change our genes is to make new ones,
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Način na koji možemo promijeniti
naše gene je da stvorimo nove,
naše gene je da stvorimo nove,
00:14
as Craig Venter has so elegantly shown.
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kao što je Craig Venter
elegantno prikazao.
elegantno prikazao.
00:16
Another is to change our lifestyles.
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Drugi način je da promijenimo
svoj način života.
svoj način života.
00:19
And what we're learning is how powerful and dynamic these changes can be,
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Saznajemo zapravo koliko ove promjene
mogu biti moćne i dinamične,
mogu biti moćne i dinamične,
00:23
that you don't have to wait very long to see the benefits.
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da ne morate čekati dugo
kako biste vidjeli rezultate.
kako biste vidjeli rezultate.
00:26
When you eat healthier, manage stress, exercise and love more,
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Kada se zdravije hranite, kontrolišete
stres, vježbate i volite više,
stres, vježbate i volite više,
00:31
your brain actually gets more blood flow and more oxygen.
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vaš mozak zapravo dobija
više krvi i kisika.
više krvi i kisika.
00:33
But more than that, your brain gets measurably bigger.
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Osim toga, vaš mozak postaje znatno veći.
00:36
Things that were thought impossible just a few years ago
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Stvari koje ste smatrali nemogućim
prije par godina
prije par godina
00:38
can actually be measured now.
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sada se zapravo mogu kontrolisati.
00:40
This was figured out by Robin Williams
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Ovo je odgonetnuo Robin Williams
00:43
a few years before the rest of us.
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par godina prije nas ostalih.
00:45
Now, there's some things that you can do
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Naime, vi možete doprinijeti tome
00:47
to make your brain grow new brain cells.
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da vaš mozak razvije nove moždane ćelije.
00:50
Some of my favorite things, like chocolate and tea, blueberries,
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Neke od stvari koje su meni najdraže:
čokolada i čaj, borovnice,
čokolada i čaj, borovnice,
00:52
alcohol in moderation, stress management
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umjerena konzumacija alkohola,
kontrolisanje stresa
kontrolisanje stresa
00:56
and cannabinoids found in marijuana.
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i kanabinoidi koje se nalaze u marihuani.
00:58
I'm just the messenger.
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Ja samo prenosim poruku.
01:01
(Laughter)
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(Smijeh)
01:04
What were we just talking about?
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O čemu smo ono pričali?
01:07
(Laughter)
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(Smijeh)
01:09
And other things that can make it worse,
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I ostale stvari koje mogu
pogoršati stvari,
pogoršati stvari,
01:11
that can cause you to lose brain cells.
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koje uzrokuju gubitak moždanih ćelija.
01:13
The usual suspects, like saturated fat and sugar,
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Tipični uzročnici kao što su
zasićene masti i šećer,
zasićene masti i šećer,
01:16
nicotine, opiates, cocaine, too much alcohol and chronic stress.
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nikotin, opijati, kokain,
previše alkohola i hronični stres.
previše alkohola i hronični stres.
01:20
Your skin gets more blood flow when you change your lifestyle,
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Vaša koža dobija veći protok krvi
kada promijenite način života,
kada promijenite način života,
01:23
so you age less quickly. Your skin doesn't wrinkle as much.
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tako da sporije starite.
Vaša koža ne dobija toliko bora.
01:26
Your heart gets more blood flow.
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Vaše srce dobija veći protok krvi.
01:28
We've shown that you can actually reverse heart disease.
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Pokazali smo da se srčana bolest
može povući.
može povući.
01:30
That these clogged arteries that you see on the upper left,
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Ove začepljene arterije koje
možete vidjeti u gornjem lijevom uglu,
možete vidjeti u gornjem lijevom uglu,
01:33
after only a year become measurably less clogged.
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mogu biti znatno manje začepljene
nakon samo jedne godine.
nakon samo jedne godine.
01:35
And the cardiac PET scan shown on the lower left,
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Kardijalno PET skeniranje
u lijevom donjem uglu,
u lijevom donjem uglu,
01:37
the blue means no blood flow.
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01:39
A year later -- orange and white is maximum blood flow.
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plavo znači da nema protoka krvi.
Nakon godinu dana narančasta i bijela
znače najveći protok.
znače najveći protok.
01:42
We've shown you may be able to stop and reverse the progression
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Pokazali smo da možete
zaustaviti napredovanje i povući
zaustaviti napredovanje i povući
01:45
of early prostate cancer and, by extension, breast cancer,
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rak prostate u ranim fazama i,
samim tim, rak dojke,
samim tim, rak dojke,
01:47
simply by making these changes.
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ako pravite ove promjene.
01:49
We've found that tumor growth in vitro was inhibited
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Otkrili smo da se spriječio
razvoj tumora in vitro
razvoj tumora in vitro
01:52
70 percent in the group that made these changes,
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70 posto u grupi
koja je pravila ove promjene,
koja je pravila ove promjene,
01:54
whereas only nine percent in the comparison group.
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a samo 9 posto u kontrolnoj grupi.
01:57
These differences were highly significant.
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Ove razlike su bile vrlo važne.
01:59
Even your sexual organs get more blood flow,
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Čak i vaši spolni organi
dobijaju veći protok krvi,
dobijaju veći protok krvi,
02:01
so you increase sexual potency.
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tako da povećavate svoju
seksualnu potenciju.
seksualnu potenciju.
02:03
One of the most effective anti-smoking ads was done
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Jednu od najefektivnijih reklama
protiv pušenja je napravio
protiv pušenja je napravio
02:05
by the Department of Health Services,
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Odjel za zdravstvene usluge,
02:07
showing that nicotine, which constricts your arteries,
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koji je pokazao da nikotin,
koji sužava arterije,
koji sužava arterije,
02:09
can cause a heart attack or a stroke,
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može izazvati srčani napad
ili moždani udar,
ili moždani udar,
02:11
but it also causes impotence.
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a može izazvati i impotenciju.
02:13
Half of guys who smoke are impotent.
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Pola muškaraca koji puše su impotentni.
02:15
How sexy is that?
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Koliko je to privlačno?
02:16
Now we're also about to publish a study --
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Uskoro ćemo objaviti prvu studiju
02:18
the first study showing you can change gene expression in men with prostate cancer.
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prema kojoj je moguća promjena
gena kod oboljelih od raka prostate.
gena kod oboljelih od raka prostate.
02:21
This is what's called a heat map --
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Ovo se zove "toplotna mapa",
02:23
and the different colors -- and along the side, on the right, are different genes.
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i različite boje, a sa desne strane
su različiti geni.
su različiti geni.
02:26
And we found that over 500 genes were favorably changed --
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Otkrili smo da se preko 500 gena
promijenilo nabolje,
promijenilo nabolje,
02:29
in effect, turning on the good genes, the disease-preventing genes,
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aktivirajući pri tome dobre gene,
koji spriječavaju bolesti,
koji spriječavaju bolesti,
02:32
turning off the disease-promoting genes.
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a deaktiviraju se geni koji potiču bolest.
Mislim da su ova jako važna otkrića,
02:36
And so these findings I think are really very powerful,
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02:39
giving many people new hope and new choices.
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a mnogim ljudima pružaju
novu nadu i nove izbore.
novu nadu i nove izbore.
02:41
And companies like Navigenics and DNA Direct and 23andMe,
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Kompanije kao što su
Navigenics, DNA Direct i 23andMe,
Navigenics, DNA Direct i 23andMe,
02:46
that are giving you your genetic profiles,
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koje vam daju vaše genetske profile,
02:49
are giving some people a sense of, "Gosh, well, what can I do about it?"
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daju nekim ljudima osjećaj,
"Bože, pa šta da radim u vezi s tim?"
"Bože, pa šta da radim u vezi s tim?"
02:52
Well, our genes are not our fate, and if we make these changes --
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Naši geni ne određuju našu sudbinu,
a ako napravimo ove promjene,
a ako napravimo ove promjene,
02:55
they're a predisposition -- but if we make bigger changes
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oni su predispozicija,
ali uz veće promjene
ali uz veće promjene
02:57
than we might have made otherwise,
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koje inače ne bismo napravili,
02:59
we can actually change how our genes are expressed.
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možemo zapravo promijeniti
način na koji se naši geni izražavaju.
način na koji se naši geni izražavaju.
03:02
Thank you.
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Hvala.
03:03
(Applause)
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(Aplauz)
ABOUT THE SPEAKER
Dean Ornish - Physician, authorDean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes.
Why you should listen
Dr. Dean Ornish wants you to live longer, and have more fun while you're at it. He's one of the leading voices in the medical community promoting a balanced, holistic approach to health, and proving that it works. The author of Eat More, Weigh Less and several other best-selling books, Ornish is best known for his lifestyle-based approach to fighting heart disease.
His research at the Preventive Medicine Research Institute (the nonprofit he founded) clinically demonstrated that cardiovascular illnesses -- and, most recently prostate cancer -- can be treated and even reversed through diet and exercise. These findings (once thought to be physiologically implausible) have been widely chronicled in the US media, including Newsweek, for which Ornish writes a column. The fifty-something physician, who's received many honors and awards, was chosen by LIFE Magazine as one of the most influential members of his generation. Among his many pursuits, Ornish is now working with food corporations to help stop America's obesity pandemic from spreading around the globe.
Dean Ornish | Speaker | TED.com