TED2009
Oliver Sacks: What hallucination reveals about our minds
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Neurologist and author Oliver Sacks brings our attention to Charles Bonnet syndrome -- when visually impaired people experience lucid hallucinations. He describes the experiences of his patients in heartwarming detail and walks us through the biology of this under-reported phenomenon.
Oliver Sacks - Neurological anthropologist
Since "Awakenings" stormed the bestseller lists (and the silver screen), Oliver Sacks has become an unlikely household name, single-handedly inventing the genre of neurological anthropology. Full bio
Since "Awakenings" stormed the bestseller lists (and the silver screen), Oliver Sacks has become an unlikely household name, single-handedly inventing the genre of neurological anthropology. Full bio
Double-click the English transcript below to play the video.
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We see with the eyes,
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but we see with the brain as well.
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And seeing with the brain is often called imagination.
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And we are familiar with the landscapes of our own imagination,
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our inscapes. We've lived with them all our lives.
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But there are also hallucinations as well,
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and hallucinations are completely different.
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They don't seem to be of our creation.
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They don't seem to be under our control.
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They seem to come from the outside,
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and to mimic perception.
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So I am going to be talking about hallucinations,
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and a particular sort of visual hallucination
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which I see among my patients.
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A few months ago, I got a phone call
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from a nursing home where I work.
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They told me that one of their residents, an old lady in her 90s,
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was seeing things,
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and they wondered if she'd gone bonkers
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or, because she was an old lady,
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whether she'd had a stroke, or whether she had Alzheimer's.
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And so they asked me if I would come and see Rosalie,
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the old lady.
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I went in to see her.
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It was evident straight away
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that she was perfectly sane
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and lucid and of good intelligence,
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but she'd been very startled and very bewildered,
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because she'd been seeing things.
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And she told me --
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the nurses hadn't mentioned this --
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that she was blind,
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that she had been completely blind from macular degeneration for five years.
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But now, for the last few days, she'd been seeing things.
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So I said, "What sort of things?"
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And she said, "People in Eastern dress,
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in drapes, walking up and down stairs.
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A man who turns towards me and smiles.
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But he has huge teeth on one side of his mouth.
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Animals too.
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I see a white building. It's snowing, a soft snow.
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I see this horse with a harness, dragging the snow away.
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Then, one night, the scene changes.
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I see cats and dogs walking towards me.
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They come to a certain point and then stop.
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Then it changes again.
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I see a lot of children. They are walking up and down stairs.
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They wear bright colors, rose and blue,
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like Eastern dress."
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Sometimes, she said, before the people come on,
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she may hallucinate pink and blue squares on the floor,
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which seem to go up to the ceiling.
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I said, "Is this like a dream?"
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And she said, "No, it's not like a dream. It's like a movie."
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She said, "It's got color. It's got motion.
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But it's completely silent, like a silent movie."
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And she said that it's a rather boring movie.
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She said, "All these people with Eastern dress,
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walking up and down, very repetitive, very limited."
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(Laughter)
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And she has a sense of humor.
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She knew it was a hallucination.
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But she was frightened. She'd lived 95 years
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and she'd never had a hallucination before.
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She said that the hallucinations were unrelated
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to anything she was thinking or feeling or doing,
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that they seemed to come on by themselves, or disappear.
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She had no control over them.
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She said she didn't recognize
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any of the people or places
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in the hallucinations.
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And none of the people or the animals,
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well, they all seemed oblivious of her.
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And she didn't know what was going on.
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She wondered if she was going mad
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or losing her mind.
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Well, I examined her carefully.
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She was a bright old lady,
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perfectly sane. She had no medical problems.
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She wasn't on any medications which could produce hallucinations.
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But she was blind.
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And I then said to her,
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"I think I know what you have."
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I said, "There is a special form of visual hallucination
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which may go with deteriorating vision or blindness.
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This was originally described," I said,
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"right back in the 18th century,
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by a man called Charles Bonnet.
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And you have Charles Bonnet syndrome.
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There is nothing wrong with your brain. There is nothing wrong with your mind.
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You have Charles Bonnet syndrome."
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And she was very relieved at this,
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that there was nothing seriously the matter,
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and also rather curious.
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She said, "Who is this Charles Bonnet?"
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She said, "Did he have them himself?"
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And she said, "Tell all the nurses
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that I have Charles Bonnet syndrome."
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(Laughter)
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"I'm not crazy. I'm not demented. I have Charles Bonnet syndrome."
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Well, so I did tell the nurses.
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Now this, for me, is a common situation.
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I work in old-age homes, largely.
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I see a lot of elderly people
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who are hearing impaired or visually impaired.
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About 10 percent of the hearing impaired people
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get musical hallucinations.
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And about 10 percent of the visually impaired people
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get visual hallucinations.
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You don't have to be completely blind,
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only sufficiently impaired.
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Now with the original description in the 18th century,
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Charles Bonnet did not have them.
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His grandfather had these hallucinations.
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His grandfather was a magistrate, an elderly man.
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He'd had cataract surgery.
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His vision was pretty poor.
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And in 1759, he described to his grandson
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various things he was seeing.
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The first thing he said was he saw
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a handkerchief in midair.
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It was a large blue handkerchief
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with four orange circles.
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And he knew it was a hallucination.
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You don't have handkerchiefs in midair.
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And then he saw a big wheel in midair.
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But sometimes he wasn't sure whether he was hallucinating or not,
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because the hallucinations would fit
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in the context of the visions.
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So on one occasion, when his granddaughters were visiting them,
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he said, "And who are these handsome young men with you?"
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And they said, "Alas, Grandpapa, there are no handsome young men."
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And then the handsome young men disappeared.
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It's typical of these hallucinations
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that they may come in a flash and disappear in a flash.
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They don't usually fade in and out.
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They are rather sudden, and they change suddenly.
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Charles Lullin, the grandfather,
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saw hundreds of different figures,
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different landscapes of all sorts.
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On one occasion, he saw a man in a bathrobe smoking a pipe,
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and realized it was himself.
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That was the only figure he recognized.
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On one occasion when he was walking in the streets of Paris,
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he saw -- this was real -- a scaffolding.
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But when he got back home, he saw a miniature of the scaffolding
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six inches high, on his study table.
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This repetition of perception
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is sometimes called palinopsia.
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With him and with Rosalie,
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what seems to be going on --
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and Rosalie said, "What's going on?" --
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and I said that as you lose vision,
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as the visual parts of the brain are no longer getting any input,
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they become hyperactive and excitable,
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and they start to fire spontaneously.
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And you start to see things.
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The things you see can be very complicated indeed.
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With another patient of mine,
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who, also had some vision,
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the vision she had could be disturbing.
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On one occasion, she said she saw
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a man in a striped shirt in a restaurant.
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And he turned around. And then
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he divided into six figures in striped shirts,
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who started walking towards her.
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And then the six figures came together again, like a concertina.
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Once, when she was driving,
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or rather, her husband was driving,
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the road divided into four
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and she felt herself going simultaneously up four roads.
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She had very mobile hallucinations as well.
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A lot of them had to do with a car.
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Sometimes she would see a teenage boy
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sitting on the hood of the car.
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He was very tenacious and he moved rather gracefully
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when the car turned.
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And then when they came to a stop,
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the boy would do a sudden vertical takeoff, 100 foot in the air,
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and then disappear.
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Another patient of mine had a different sort of hallucination.
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This was a woman who didn't have trouble with her eyes,
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but the visual parts of her brain,
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a little tumor in the occipital cortex.
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And, above all, she would see cartoons.
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These cartoons would be transparent
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and would cover half the visual field, like a screen.
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And especially she saw cartoons of Kermit the Frog.
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(Laughter)
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Now, I don't watch Sesame Street,
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but she made a point of saying,
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"Why Kermit?" She said, "Kermit the Frog means nothing to me.
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You know, I was wondering about Freudian determinants.
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Why Kermit?
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Kermit the Frog means nothing to me."
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She didn't mind the cartoons too much.
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But what did disturb her was she got very persistent
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images or hallucinations of faces
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and as with Rosalie, the faces were often deformed,
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with very large teeth or very large eyes.
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And these frightened her.
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Well, what is going on with these people?
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As a physician, I have to try and define what's going on,
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and to reassure people,
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especially to reassure them that they're not going insane.
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Something like 10 percent, as I said,
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of visually impaired people get these.
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But no more than one percent of the people acknowledge them,
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because they are afraid they will be seen as insane or something.
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And if they do mention them to their own doctors
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they may be misdiagnosed.
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In particular, the notion is that if you see
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things or hear things, you're going mad,
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but the psychotic hallucinations are quite different.
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Psychotic hallucinations, whether they are visual or vocal,
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they address you. They accuse you.
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They seduce you. They humiliate you.
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They jeer at you.
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You interact with them.
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There is none of this quality of being addressed
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with these Charles Bonnet hallucinations.
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There is a film. You're seeing a film which has nothing to do with you,
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or that's how people think about it.
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There is also a rare thing called temporal lobe epilepsy,
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and sometimes, if one has this,
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one may feel oneself transported back
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to a time and place in the past.
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You're at a particular road junction.
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You smell chestnuts roasting.
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You hear the traffic. All the senses are involved.
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And you're waiting for your girl.
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And it's that Tuesday evening back in 1982.
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And the temporal lobe hallucinations
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are all-sense hallucinations,
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full of feeling, full of familiarity,
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located in space and time,
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coherent, dramatic.
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The Charles Bonnet ones are quite different.
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So in the Charles Bonnet hallucinations,
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you have all sorts of levels,
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from the geometrical hallucinations --
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the pink and blue squares the woman had --
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up to quite elaborate hallucinations
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with figures and especially faces.
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Faces, and sometimes deformed faces,
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are the single commonest thing
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in these hallucinations.
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And one of the second commonest is cartoons.
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So, what is going on?
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Fascinatingly, in the last few years,
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it's been possible to do functional brain imagery,
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to do fMRI on people as they are hallucinating.
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And in fact, to find that different parts
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of the visual brain are activated
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as they are hallucinating.
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When people have these simple geometrical hallucinations,
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the primary visual cortex is activated.
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This is the part of the brain which perceives edges and patterns.
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You don't form images with your primary visual cortex.
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When images are formed,
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a higher part of the visual cortex
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is involved in the temporal lobe.
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And in particular, one area of the temporal lobe
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is called the fusiform gyrus.
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And it's known that if people have damage in the fusiform gyrus,
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they maybe lose the ability to recognize faces.
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But if there is an abnormal activity in the fusiform gyrus,
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they may hallucinate faces,
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and this is exactly what you find in some of these people.
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There is an area in the anterior part of this gyrus
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where teeth and eyes are represented,
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and that part of the gyrus is activated
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when people get the deformed hallucinations.
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There is another part of the brain
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which is especially activated
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when one sees cartoons.
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It's activated when one recognizes cartoons,
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when one draws cartoons, and when one hallucinates them.
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It's very interesting that that should be specific.
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There are other parts of the brain which are specifically involved
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with the recognition and hallucination
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of buildings and landscapes.
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Around 1970, it was found that there were not only parts of the brain,
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but particular cells.
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"Face cells" were discovered around 1970.
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And now we know that there are hundreds of other
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sorts of cells,
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which can be very, very specific.
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So you may not only have
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"car" cells,
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you may have "Aston Martin" cells.
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(Laughter)
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I saw an Aston Martin this morning.
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I had to bring it in.
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And now it's in there somewhere.
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(Laughter)
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Now, at this level, in what's called the inferotemporal cortex,
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there are only visual images,
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or figments or fragments.
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It's only at higher levels
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that the other senses join in
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and there are connections with memory and emotion.
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And in the Charles Bonnet syndrome,
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you don't go to those higher levels.
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You're in these levels of inferior visual cortex
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where you have thousands and tens of thousands
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and millions of images,
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or figments, or fragmentary figments,
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all neurally encoded
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in particular cells or small clusters of cells.
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Normally these are all part of
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the integrated stream of perception, or imagination,
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and one is not conscious of them.
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It is only if one is visually impaired or blind
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that the process is interrupted.
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And instead of getting normal perception,
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you're getting an anarchic,
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convulsive stimulation, or release,
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of all of these visual cells
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in the inferotemporal cortex.
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So, suddenly you see a face. Suddenly you see a car.
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Suddenly this, and suddenly that.
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The mind does its best to organize
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and to give some sort of coherence to this,
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but not terribly successfully.
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When these were first described,
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it was thought that they could be interpreted like dreams.
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But in fact people say,
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"I don't recognize the people. I can't form any associations."
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"Kermit means nothing to me."
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You don't get anywhere thinking of them as dreams.
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Well, I've more or less said what I wanted.
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I think I just want to recapitulate
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and say this is common.
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Think of the number of blind people.
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There must be hundreds of thousands of blind people
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who have these hallucinations,
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but are too scared to mention them.
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So this sort of thing needs to be brought into
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notice, for patients, for doctors, for the public.
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Finally, I think they are
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infinitely interesting and valuable,
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for giving one some insight as to how the brain works.
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Charles Bonnet said, 250 years ago --
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he wondered how, thinking these hallucinations,
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how, as he put it, the theater of the mind
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could be generated by the machinery of the brain.
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Now, 250 years later,
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I think we're beginning to glimpse how this is done.
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Thanks very much.
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(Applause)
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Chris Anderson: That was superb. Thank you so much.
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You speak about these things with so much insight
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and empathy for your patients.
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Have you yourself experienced any of the syndromes you write about?
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Oliver Sacks: I was afraid you'd ask that.
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(Laughter)
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Well, yeah, a lot of them.
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And actually I'm a little visually impaired myself.
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I'm blind in one eye, and not terribly good in the other.
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And I see the geometrical hallucinations.
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But they stop there.
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CA: And they don't disturb you?
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Because you understand what's doing it, it doesn't make you worried?
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OS: Well they don't disturb me any more than my tinnitus,
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which I ignore.
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They occasionally interest me,
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and I have many pictures of them in my notebooks.
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I've gone and had an fMRI myself,
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to see how my visual cortex is taking over.
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And when I see all these hexagons
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and complex things, which I also have,
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in visual migraine,
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I wonder whether everyone sees things like this,
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and whether things like cave art or ornamental art
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may have been derived from them a bit.
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CA: That was an utterly, utterly fascinating talk.
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Thank you so much for sharing.
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OS: Thank you. Thank you.
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(Applause)
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ABOUT THE SPEAKER
Oliver Sacks - Neurological anthropologistSince "Awakenings" stormed the bestseller lists (and the silver screen), Oliver Sacks has become an unlikely household name, single-handedly inventing the genre of neurological anthropology.
Why you should listen
Oliver Sacks was a ground-breaking neurologist -- and a gifted storyteller who enriched our knowledge of the infinite variations of human psychology. After his pioneering work with “sleepy sickness” patients (who were in fact survivors of an early-20th-century pandemic), Sacks went on to study the connections between music and the brain, as well as disorders such as Tourette's syndrome, Parkinson's disease, and many other little-understood disorders that often count Sacks as one of their first chroniclers.
Sacks was well known as a writer of such best-selling case histories as Hallucinations, The Man Who Mistook His Wife for a Hat, An Anthropologist on Mars, and his memoir of his early work, Awakenings, all of which have breathed new life into the dusty 19th-century tradition of the clinical anecdote. Sacks' writing, compassion and wide-ranging knowledge catapults the genre into the 21st century and brings the far frontiers of neurological experience into the view of millions of readers worldwide. Sacks died at age 82 in August 2015.
Read TED's long, wonderful Q&A with Oliver Sacks >>
Oliver Sacks | Speaker | TED.com